Mediation Role Research Articles

Pain and daily interference among reproductive-age women with myofascial pelvic pain: Serial mediation roles of kinesiophobia, self-efficacy and pain catastrophizing.

Myofascial pelvic pain (MFPP), which is identified by tender points in the pelvic floor musculature, is a prevalent source of chronic pelvic pain in women. It may lead to physical and mental exhaustion, reproductive concerns, and coping difficulties in daily life and work than the disease itself. Pain-related cognitive processes can affect pain relief and quality of life. Kinesiophobia, self-efficacy and pain catastrophizing are frequently treated as mediators between pain and its related consequences. Greater kinesiophobia and pain catastrophizing have been shown to be associated with adverse functional outcomes, while higher self-efficacy has been related with improved quality of life. Regarding MFPP in females of childbearing age, it remains unclear whether the effects of kinesiophobia, self-efficacy and pain catastrophizing on daily interference are direct or indirect; the influence on each variable is, therefore, not entirely evident. The present study aimed to evaluate the relationship between pain and daily interference in reproductive-age women with MFPP through kinesiophobia, self-efficacy and pain catastrophizing, as well as to identify areas for future investigation and intervention based on the data collected from this population. This is a multi-center cross-sectional study. The study was conducted from November 15, 2022 to November 10, 2023, 202 reproductive-age women with MFPP were recruited from 14 hospitals in ten provinces of China. The demographic variables, Brief Pain Inventory, Tampa Scale of Kinesiophobia, Pain Self-Efficacy Questionnaire, and Pain Catastrophizing Scale were used to measure the participants' related information. The data was described and analyzed using Descriptive analyses, Pearson correlation analysis, and Serial mediation modeling. Pain not only had a direct positive impact (B = 0.575; SE = 0.081; 95%CI: LL = 0.415, UL = 0.735) on daily interference, but also had an indirect impact on daily interference through the independent mediating role of pain catastrophizing (B = 0.088; SE = 0.028; 95%CI: LL = 0.038, UL = 0.148), the chain mediating of kinesiophobia and catastrophizing (B = 0.057; SE = 0.019; 95%CI: LL = 0.024, UL = 0.098), and the four-stage serial mediating of kinesiophobia, self-efficacy and catastrophizing (B = 0.013; SE = 0.006; 95%CI: LL = 0.003, UL = 0.027). The proposed serial mediation model showed a good fit with the collected data. The findings illustrate the significance of addressing pain catastrophizing and kinesiophobia (especially catastrophizing), and increasing self-efficacy in pain therapy, and suggest that functional recovery be integrated into pain therapy for reproductive-age women suffering from MFPP.

Reconciliation of the parties: the role of mediation in the resolution of administrative conflicts

Reconciliation of the parties: the role of mediation in the resolution of administrative conflicts

The mediation role of emotion regulation strategies on the relationship between mindfulness effects, psychological well-being and distress among youths: findings from a randomized controlled trial

AbstractThe Gaia program is a 12-week mindfulness intervention based on cultivating body, emotional, and ecological self-awareness, which has been shown to be effective in reducing children’s and adolescents’ internalizing problems, and improving psychological well-being, and psychological distress in early adolescents. To clarify the psychological processes underlying mindfulness effects on mental health among adolescents, the present study aimed to examine whether emotion regulation strategies (i.e., cognitive reappraisal and expressive suppression) may be considered as key processes linking the Gaia program effects to improvements in psychological distress and well-being. A total of 361 adolescents (mean age 14 years) were randomly assigned to one of two groups: the Gaia program (i.e., experimental group; N = 210) and waiting list (i.e., control group; N = 151). Measures were administered at three time points, approximately every three months: one week before treatment, one week after treatment, and three months after treatment. Using a structural equation model (SEM), we found that the Gaia Program had a positive and significant indirect effect on psychological well-being only via cognitive reappraisal as measured at follow-up [B = 0.181, 95% C.I. (0.012; 0.395)], whereas no significant indirect effects were found on psychological distress through cognitive reappraisal and expressive suppression. Findings from this study provide evidence of key emotional processes underlying the effects of a mindfulness intervention on positive but not negative psychological outcomes.

Religious coping and delinquent behaviors: Moderated mediation roles of religion affiliation and prosocial moral reasoning.

Religion has been shown to have a positive impact for developing adolescents; however, the processes underlying this relation are not well known. In his almighty prosocial theory, Anazonwu (Conceptualizing and testing almighty prosociality theory for a more peaceful world, SCOA Heritage Nigeria, 2017) proposed that the activation of learnt prosocial moral reasoning through religion enabled performance of prosocial peace behavior that will benefit society. Thus, religion coping enhances the development of prosocial reasoning which in turn propagate prosocial acts while reducing delinquent behaviors. Similarly, developmental system theory (Lerner, Developmental science, developmental systems, and contemporary theories of human development, John Wiley & Sons, 2006) assumed that in every individual three mechanisms: plasticity (potential to change), context (environment), and developmental regulation (learnable principles) interact to describe the direction of the transactions between individuals and their various embedded sociocultural context of development which will also determine other developmental outcomes. Based on these two theoretical assumptions, the present study examined whether prosocial moral reasoning (developmental regulation) was the mechanism in the negative correlation between religious coping (plasticity) and delinquent behaviors (outcome), and if religious affiliation(context) (Christianity and Islam) moderated these paths. We hypothesized that the link from prosocial moral reasoning to lower delinquent behaviors would be stronger for Muslim compared with Christian youth. These questions were tested among Nigerian adolescence, an important sample because of high interreligious and interethnic tension among youth in the country. 298 adolescents (Mean age = 15.03 years, SD = 1.76; male = 176, female = 122; 46.3% Muslim, 53.7% Christian) were sampled using questionnaires in senior secondary schools in Nigeria. Moderated mediation result shows that greater religious coping was linked with higher prosocial moral reasoning, which in turn predicted fewer delinquent behaviors. Religious coping interacted with religion affiliation to influence delinquent behavior; there was a stronger link between these two constructs for Muslim compared to Christian youth. Thus, interventions aiming to reduce youth delinquent behaviors should consider promoting prosocial moral reasoning, particularly among the various religions (i.e., Christian/Muslim) communities.

NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.

The expression of Neuritin-1 (NRN1), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor (BDNF). Although the receptor of NRN1 remains unclear, it is suggested that NRN1's activation of the insulin receptor (IR) pathway promotes the transcription of the calcium voltage-gated channel subunit alpha1 C (CACNA1C). These three genes have been independently associated with schizophrenia (SZ)risk, symptomatology, and brain differences. However, research on how they synergistically modulate these phenotypes is scarce. We aimed to study whether the genetic epistasis between these genes affects the risk and clinical presentation of the disorder via its effect on brain structure. First, we tested the epistatic effect of NRN1 and BDNF or CACNA1C on (i) the risk for SZ, (ii) clinical symptoms severity and functionality (onset, PANSS, CGI and GAF), and (iii) brain cortical structure (thickness, surface area and volume measures estimated using FreeSurfer) in a sample of 86 SZ patients and 89 healthy subjects. Second, we explored whether those brain clusters influenced by epistatic effects mediate the clinical profiles. Although we did not find a direct epistatic impact on the risk, our data unveiled significant effects on the disorder's clinical presentation. Specifically, the NRN1-rs10484320 x BDNF-rs6265 interplay influenced PANSS general psychopathology, and the NRN1-rs4960155 x CACNA1C-rs1006737 interaction affected GAF scores. Moreover, several interactions between NRN1 SNPs and BDNF-rs6265 significantly influenced the surface area and cortical volume of the frontal, parietal, and temporal brain regions within patients. The NRN1-rs10484320 x BDNF-rs6265 epistasis in the left lateral orbitofrontal cortex fully mediated the effect on PANSS general psychopathology. Our study not only adds clinical significance to the well-described molecular relationship between NRN1 and BDNF but also underscores the utility of deconstructing SZ into biologically validated brain-imaging markers to explore their mediation role in the path from genetics to complex clinical manifestation.

The Impact of Individualism/Collectivism and Masculinity/Femininity on Brand Loyalty: A Mediation Role of Perceived Ease of Use

Cultural dimensions have varying impacts on brand loyalty. This signifies that each cultural dimension is associated with brand loyalty in different ways. The influence of individualism/collectivism and masculinity/femininity dimensions on brand loyalty is dependent on the levels of these dimensions in different countries. Given the significance of cultural dimensions in relation to brand loyalty, this study aims to investigate the impact of individualism/collectivism and masculinity/femininity on brand loyalty, while also exploring the mediating role of perceived ease of use. The data for this study was collected through an online survey questionnaire, with a total of 501 respondents participating. The collected data was analyzed using Partial Least Square Structural Equation Modeling (PLS-SEM). The findings of the study revealed that both individualism/collectivism and masculinity/femininity dimensions have significant effects on brand loyalty. Additionally, the study indicated that masculinity/femininity dimension significantly impacts perceived ease of use. Furthermore, the study found that perceived ease of use partially mediates the relationship between masculinity/femininity dimensions and brand loyalty. Perceived ease of use was also found to have a significant positive effect on brand loyalty. This study contributes to the existing literature on brand loyalty by providing insights into the effects of individualism/collectivism and masculinity/femininity on brand loyalty. Additionally, it contributes to understanding the mediating effect of perceived ease of use in the relationship between individualism/collectivism, masculinity/femininity, and brand loyalty.

Emotion Regulation Difficulties and Callous-Unemotional Traits: The Role of Guilt Across Samples of Incarcerated Male Adult Offenders

ABSTRACT The study aimed to: (1) analyze differences between psychopathic and non-psychopathic offenders in terms of difficulties in emotion regulation and callous-unemotional traits, (2) investigate the association between difficulties in emotion regulation and callous-unemotional traits among psychopathic and non-psychopathic offenders, and (3) examine the mediation role of guilt in the relationship between difficulties in emotion regulation and callous-unemotional traits among non-psychopathic offenders, controlling for the level of desirable responses. The participants were 191 incarcerated male adult offenders serving their sentences in closed and semi-open custody. The incarcerated offenders participated in a semi-structured interview and completed self-report measures of emotion dysregulation, guilt, callous-unemotional traits, and social desirability. According to the results on the Hare Psychopathy Checklist-Revised, 60 (27.9%) participants were included in the psychopathic group, while 131 (60.9%) were non-psychopathic. The results showed a positive relationship between difficulties in emotion regulation, callousness, and psychopathy. The multiple regression analysis indicated that guilt contributed to the variance of callousness. Guilt was a mediator in the relationship between difficulties in emotion regulation and callousness among the group of non-psychopathic incarcerated offenders. The current study highlighted the importance of guilt as an adaptive moral emotion useful in the treatment of several psychological problems among male offenders.

Associations between parental autonomy support and depressive symptoms among Chinese college students: the chain-mediating effects of mindfulness and self-esteem

IntroductionDespite extensive research on contextual factors will relieve college students’ depressive symptoms, significant gaps remain in understanding the underlying mechanisms of this relationship, particularly through individual strength factors such as mindfulness and self-esteem. Based on self-determination theory, we explore the association between parental autonomy support and depressive symptoms among Chinese college students and whether mindfulness and self-esteem serve as mediators.MethodsA total of 1,182 Chinese college students aged 16 to 27 years (Mage = 20.33, SD = 1.63; female = 55.7%) participated in this research. Questionnaires pertaining to parental autonomy support, mindfulness, self-esteem, and depressive symptoms were administered.ResultsThe results revealed that depressive symptoms were negatively correlated with both paternal and maternal autonomy support, with mindfulness and self-esteem acting as chain-mediators. Specifically, mindfulness and self-esteem were positively impacted by parental autonomy support, whereas depressive symptoms were negatively impacted by mindfulness and self-esteem. Furthermore, paternal and maternal autonomy support significantly impacted depressive symptoms via both direct and indirect pathways. Indirect effects included three paths: mediation through mindfulness, mediation through self-esteem, and mediation through the mindfulness and self-esteem chain.DiscussionThe study highlights the fundamental mechanisms that account for the association between Chinese college students’ parental autonomy support and depressive symptoms, these insights can be used to prevent and manage mental health problems among Chinese college students. For example, parents’ autonomy support can directly reduce depressive symptoms, but we can also indirectly promote college students’ mental health by emphasizing the mediation role of students’ mindfulness and self-esteem.

Invasiveness, privacy concerns and mobile banking services technology adoption by millennials: Emerging economy perspective

Purpose: This study was conceptualised to investigate the relationships of invasiveness, privacy concerns, perceived usefulness and the adoption of mobile marketing technology by millennial banking customers in an emerging market economy.Design/methodology/approach: This was a quantitative study that targeted millennial banking service customers from an emerging market environment. The non-probability sampling approach was used, and the data were collected via a survey questionnaire. For data analysis, SPSS and SmartPLS Structural equation modeling were used.Findings/results: The results confirmed a direct relationship between privacy, invasiveness and usefulness perception. It also confirmed a direct relationship between perceived usefulness and the intention to accept mobile-marketed banking services. In addition, the results also showed that in addition to the direct impact of perceived usefulness on intention to adopt mobile marketing usage for banking services, it acts as a mediator variable.Practical implications: Academics can pursue a qualitative study to unpack the reasons for sensitivity around banking technology in emerging markets. The study should lead to better understanding of both the investigated market and others like it. Organisations will gain valuable insight for informed investment in such markets.Originality/value: The article is the first empirical investigation into the adoption of mobile-marketed banking services by millennials in a developing economy context. The study adds a valuable component to academic debates by using two independent theories to gain a holistic view of the performance of advanced technology in banking business. The study adds to the literature by also proving the mediation role of perceived technology usefulness in banking.

A study on the double-edged sword effect of inclusive leadership on employees’ work behaviour—dual path perspective of cognition and affection

In order to cope with the volatile social environment and organisational change, more and more scholars call on leaders to stimulate subordinate effectiveness to a greater extent with inclusive behaviour. Existing studies focus on the positive impact of inclusive leadership, but ignore its potential negative impact. This study integrates Cognition-affection Personality System Theory to explore the double-edged sword mechanism of inclusive leadership on subordinates’ work behaviour. Through the data analysis of 518 paired questionnaires collected in three stages, the results are as follows: Inclusive leadership has a positive impact on subordinates’ psychological entitlement and state gratitude; Psychological entitlement and state gratitude play mediation roles not only between inclusive leadership and work withdrawal behaviour, but also between inclusive leadership and active behaviour; Subordinate narcissistic personality moderates the positive effect of inclusive leadership on psychological entitlement and state gratitude, and then moderates the indirect effect of inclusive leadership on subordinate work withdrawal behaviour and proactive behaviour through psychological entitlement and state gratitude. The above results expand the research on the action mechanism and boundary conditions of inclusive leadership in Chinese organisational context, and provide practical guidance for organisational managers to effectively conduct inclusive leadership.

The Influence of It Governance and It Capability on The Performance of Private Higher Education Institutions: The Mediation Role of Performance Management Systems

This study examines the effect of information technology (IT) governance and IT capability on the organizational performance of private Higher Education Institutions (HEI) with a performance management system as a mediating variable. This quantitative study uses primary data from questionnaires distributed to respondents online. Respondents in this study were 270 management and IT management of private universities on the island of Sumatra. This study used a sample of 90 private HEIs. Furthermore, the data was processed using Partial Least Square (PLS) technique. The results are that the performance management system partially mediates IT governance with organizational performance, while IT capability mediates fully with organizational performance. IT capabilities can encourage organizational performance through a good performance management system. Theoretically, it contributes to implementing technological resources mobilized in the performance management system to improve college performance. College management should consider developing technology and performance measurement systems to achieve sustainable competitive advantage.

Association between homocysteine and blood pressure in the NHANES 2003–2006: the mediating role of Vitamin C

BackgroundThe yearly escalation in hypertension prevalence signifies a noteworthy public health challenge. Adhering to a nutritious diet is crucial for enhancing the quality of life among individuals managing hypertension. However, the relationship between vitamin C and hypertension, as well as homocysteine, remains unclear.ObjectiveThe primary aim of this investigation was to scrutinize the potential mediating role of Vitamin C in the association between homocysteine levels and blood pressure, utilizing data extracted from the National Health and Nutrition Examination Survey (NHANES) database.MethodsA total of 7,327 participants from the NHANES 2003–2006 were enrolled in this cross-sectional survey. The main information was obtained using homocysteine, Vitamin C, systolic blood pressure (SBP) and diastolic blood pressure (DBP). Correlation analysis was used to assess the correlation between homocysteine, SBP, DBP and vitamin C. Linear regression analysis was utilized to determine the β value (β) along with its 95% confidence intervals (CIs). Mediation analysis was performed to investigate whether the relationship between homocysteine and blood pressure was mediated by Vitamin C, and to quantify the extent to which Vitamin C contributed to this association.ResultsThe results manifested that the homocysteine was positively associated with SBP (r = 0.24, p < 0.001) and DBP (r = 0.03, p < 0.05), while negatively correlated with Vitamin C (r = −0.008, p < 0.001). Vitamin C was found to be negatively associated with SBP (r = −0.03, p < 0.05) and DBP (r = 0.11, p < 0.001). Mediation effect analysis revealed that a partial mediation (indirect effect: 0.0247[0.0108–0.0455], p < 0.001) role accounting for 11.5% of total effect, among homocysteine and SBP. However, the mediating effect of Vitamin C between homocysteine and DBP was not statistically significant.ConclusionHypertension patients should pay attention to homocysteine and Vitamin C level. What is more, hypertension patients ought to formulate interventions for Vitamin C supplementation as well as homocysteine reduce strategies to lower blood pressure.

Resolving the adaptive performance problems in the public sector using purposeful leadership: an empirical investigation in Ghana

PurposePerformance problems in the public sector (PS) necessitate adaptation due to the sector’s uniqueness. Purposeful leadership (PL) may resolve PS adaptive performance (AP) problems. However, there is a paucity of research on the influence of PL on AP. Using data from three large PS organisations in Ghana, this research explores the relationship between PL and AP through job satisfaction (JS) and organisational identification (OI). It also explores the moderating effect of organisational integrity (IN) on the PL–JS and PL–OI relationships.Design/methodology/approachThis paper created and tested a research model using the responses of 875 public servants in Smart PLS 4. Contract fulfilment and perceived organisational support functioned as control factors influencing JS (an intervener). Perceived procedural justice and psychological need satisfaction serve as control factors for OI (another intervener). Age, sex, tenure, education and job position were used as control variables in AP. To assess the role of moderation, we utilised the product indicator approach, and to estimate the role of mediation, we used variance accounted for (VAF). A significance level of 5% was established.FindingsAs anticipated, this study found that PL and AP had a significantly positive connection (t = 2.229, p = 0.000, β = 0.138). Both JS (VAF = 27.37%) and OI (VAF = 39.21%) partially mediated this connection. IN positively moderated the PL–JS (t = 4.249, p = 0.000, β = 0.165) and PL–OI (t = 3.704, p = 0.002, β = 0.099) connections.Research limitations/implicationsThis paper provides a theoretical and empirical understanding of the PL–AP relationship, how this relationship is facilitated and how the PL–JS and PL–OI relationships are strengthened. It provides a roadmap for upcoming scholars to test the hypotheses in diverse PS contexts globally to broaden the field of leadership. It will be insightful to show how JS and OI jointly mediate this relationship and the potential mediating role of job embeddedness in further studies.Practical implicationsHuman resource (HR) practices in PS organisations, such as selecting, leadership enhancement initiatives, promotions, training and performance evaluations, must be guided by a “values-driven strategy” if leadership is to find, cultivate and keep employees capable of devising innovative strategies to manage unforeseen circumstances at work. The leaders are required to demonstrate the values of their organisations in order to set up a role model.Social implicationsThis study highlights the obstacles that purposeful leaders have the potential to mitigate, as well as the prospects that they might offer. It shows the essence for PS organisations to uphold and maintain high integrity standards as their hallmark.Originality/valueThis paper is the first to create and test a research model that shows the relationship between PL and AP. It also shows the different mechanisms (JS and OI) that make this effect possible, as well as the good work environment (i.e. IN) that allows the PL–JS and PL–OI relationships to grow.

Augmented reality: the key to unlock customer engagement potential

PurposeThis study aims to investigate the impact of customer perceptions of Augmented Reality (AR) attributes such as augmentation, interactivity and vividness on attitudes towards AR mobile apps, virtual product and behavioural intentions. Also, the mediation role of customer engagement in the effect of perceptions of AR attributes on attitudes and behavioural intentions is examined using the Theory of Interactive Media Effects.Design/methodology/approachThe study used a cross-sectional design. A total of 456 valid data were collected from the Millennials and Generation Z cohorts using purposive sampling. The conceptual framework was assessed using Partial Least Squares-Structural Equation Modelling (PLS-SEM) and Partial Least Squares-Multi Group Analysis (PLS-MGA).FindingsThe research revealed that customer perceptions of AR features such as augmentation, interactivity and vividness significantly influenced customer engagement, leading to favourable attitudes towards both the AR mobile app and the Virtual product as well as behavioural intentions. Furthermore, the study substantiates the role of customer engagement as a mediator in the relationship between customer perceptions of AR attributes and both attitudinal and behavioural outcomes.Originality/valueTo the best of the authors’ knowledge, this is the first attempt to investigate the significance of perceived augmentation as an antecedent to customer engagement and the mediating role of customer engagement on the influence of perceptions of AR attributes on attitudinal and behavioural intention.

Linking information technology use with corporate entrepreneurship: The mediation role of openness to external knowledge

AbstractFirms are increasingly applying multiple information technologies (ITs) to pursue corporate entrepreneurship. However, how different ITs can be leveraged collectively to achieve corporate entrepreneurship remains largely underexplored. Drawing upon the knowledge‐based view, we develop an integrative theoretical model to delineate how three types of commonly deployed IT (i.e. organisational enterprise systems use, organisational social media use and top management team social media use) can be used collectively in the knowledge acquisition and utilisation processes to achieve corporate entrepreneurship. Specifically, we posit that organisational IT uses (i.e. organisational enterprise systems use and organisational social media use) enhance openness to external knowledge in the knowledge acquisition process, which in turn serves as the mediation mechanism to channel organisational IT uses into corporate entrepreneurship. Moreover, top management team IT use (i.e. top management team social media use) shapes the effect of openness to external knowledge on corporate entrepreneurship in the knowledge utilisation process. The empirical analysis using multi‐respondent survey data from 1252 managers in 313 firms provides strong support for the proposed model. This study contributes to the information systems research on how IT influences corporate entrepreneurship by distinguishing the roles of organisational enterprise systems use, organisational social media use and top management team social media use in enhancing corporate entrepreneurship through firms' openness to external knowledge.

Hospitalization expenses of coronary heart disease inpatients in China: evidence from two hospitals in Ningxia Hui autonomous region

AimThe increasing morbidity from coronary health disease (CHD) has imposed a significant social and economic burden in China. We analyzed the factors affecting hospitalization expenses of CHD patients.DesignFrom 2012 to 2018, data on 16,726 CHD patients were collected from the hospital information system in Ningxia Hui Autonomous Region.MethodsA multiple ordered logistic regression model was used to analyze the factors affecting hospitalization expenses.ResultsThe average hospitalization expense was RMB30998.26 ± 29890.03. Hospital materials expenses accounted for roughly 60% of total hospitalization costs. The older adult, patients who were male, in critical health status, with longer hospital stays, unemployed, using antibiotics and undergoing an operation without incision had significantly raised hospital expenses, while those with fewer complications, no operations and self-paying for health care had reduced hospitalization costs (p < 0.05). The length of hospital stay played a partial mediator role (p < 0.05).Public contributionControlling the increase of medical materials costs and preventing over-consumption of hospital services by insured patients are recommended.

Association of healthy diet score and adiposity with risk of colorectal cancer: findings from the UK Biobank prospective cohort study.

To explore the joint association of dietary patterns and adiposity with colorectal cancer (CRC), and whether adiposity mediates the relationship between dietary patterns and CRC risk, which could provide deeper insights into the underlying pathogenesis of CRC. The data of 307,023 participants recruited between 2006 and 2010 were extracted from the UK Biobank study. Healthy diet scores were calculated based on self-reported dietary data at baseline, and participants were categorized into three groups, namely, low, intermediate, and high diet score groups. Cox regression models with hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the effects of the healthy diet score on CRC incidence, adjusting for various covariates. Furthermore, the mediation roles of obesity and central obesity between the healthy diet score and CRC risk were assessed using a counterfactual causal analysis based on Cox regression model. Additionally, joint association between dietary patterns and adiposity on CRC risks was assessed on the additive and multiplicative scales. Over a median 6.2-year follow-up, 3,276 participants developed CRC. After adjusting for sociodemographic and lifestyle factors, a lower risk of CRC incidence was found for participants with intermediate (HR = 0.83, 95% CI: 0.72 to 0.95) and high diet scores (HR = 0.73, 95% CI: 0.62 to 0.87) compared to those with low diet scores. When compared with the low diet score group, obesity accounted for 4.13% and 7.93% of the total CRC effect in the intermediate and high diet score groups, respectively, while central obesity contributed to 3.68% and 10.02% of the total CRC risk in the intermediate and high diet score groups, respectively. The mediating effect of adiposity on CRC risk was significant in men but not in women. Concurrent unhealthy diet and adiposity multiplied CRC risk. Adiposity-mediated effects were limited in the link between dietary patterns and CRC incidence, implying that solely addressing adiposity may not sufficiently reduce CRC risk. Interventions, such as improving dietary quality in people with adiposity or promoting weight control in those with unhealthy eating habits, may provide an effective strategy to reduce CRC risk.

The Relationship Between Emotional Intelligence and Career Decision-Making Difficulties: Mediation Role of Career Adaptability of University Students

Rapid changes in the global marketplace and invisible pressures have made career decision-making challenging for students. This article explores the relationship between emotional intelligence and career decision difficulties, as well as the mediating role of career adaptability, in a cross-sectional study conducted among students. A total of 265 students from Ho Chi Minh City, Vietnam (Mage = 19.99; SD = 1.46) were randomly selected and participated through an online questionnaire. The study employed the Career Decision-making Difficulties Questionnaire, which includes 34 questions to assess career decision-making difficulties; the Wong and Law Emotional Intelligence Scale, comprising 16 items to measure emotional intelligence; and the Career Adapt-Abilities Scale - Short Form with 12 items to evaluate career adaptability. The findings reveal two primary outcomes: (1) emotional intelligence significantly negatively impacts career decision difficulties (effect = -0.15, p < .05, 95% CI = [-0.29, -0.01]), and (2) career adaptability significantly mediates this relationship (effect = -0.11, 95% CI = [-0.20, -0.02]). These results suggest that enhancing emotional intelligence and career adaptability may facilitate improved career decision-making among students.

Heterogeneity of aging and mortality risk among individuals with hypertension: Insights from phenotypic age and phenotypic age acceleration

ObjectivesHypertension, a key contributor to mortality, is impacted by biological aging. We investigated the relationship between novel biological aging metrics - Phenotypic Age (PA) and Phenotypic Age Acceleration (PAA) - and mortality in individuals with hypertension, exploring the mediating effects of arterial stiffness (estimated Pulse Wave Velocity, ePWV), and Heart/Vascular Age (HVA). MethodsUsing data from 62,160 National Health and Nutrition Examination Survey (NHANES) participants (1999–2010), we selected 4,228 individuals with hypertension and computed PA, PAA, HVA, and ePWV. Weighted, multivariable Cox regression analysis yielded Hazard Ratios (HRs) relating PA, PAA to mortality, and mediation roles of ePWV, PAA, HVA were evaluated. Mendelian randomization (MR) analysis was employed to investigate causality between genetically inferred PAA and hypertension. ResultsOver a 12-year median follow-up, PA and PAA were tied to increased mortality risks in individuals with hypertension. All-cause mortality hazard ratios per 10-year PA and PAA increments were 1.96 (95% CI, 1.81–2.11) and 1.67 (95% CI, 1.52–1.85), respectively. Cardiovascular mortality HRs were 2.32 (95% CI, 1.97–2.73) and 1.93 (95% CI, 1.65–2.26) for PA and PAA, respectively. ePWV, PAA, and HVA mediated 42%, 30.3%, and 6.9% of PA’s impact on mortality, respectively. Mendelian randomization highlighted a causal link between PAA genetics and hypertension (OR = 1.002; 95% CI, 1.000–1.003). ConclusionPA and PAA, enhancing cardiovascular risk scores by integrating diverse biomarkers, offer vital insights for aging and mortality evaluation in individuals with hypertension, suggesting avenues for intensified aging mitigation and cardiovascular issue prevention. Validations in varied populations and explorations of underlying mechanisms are warranted.

Association of residential exposure to air pollution and ANRIL expression in adults with and without ischemic stroke in Iran: a cross-sectional study

Air pollution exposures including particulate matter (PM) have been related with genotoxic effects; however, the evidence on such associations with ANRIL (a long non-coding RNA) expression is not clear yet. Therefore, this study for the first time aimed to investigate the association between PM exposure at residential addresses and ANRIL expression. Moreover, the risk of ischemic stroke (IS) related PM exposure, as well as ANRIL expression and finally, the mediation role of ANRIL on IS occurrence, were assessed. A total of 186 patients with IS and 187 healthy controls who were age, gender and body mass index (BMI)-matched were recruited for this study in Sabzevar, Iran (2019-20). PM1, PM2.5, and PM10 at participants' homes were estimated using spatiotemporal models developed for Sabzevar. The ANRIL expression was measured using real-time PCR. The linear regression models were applied to assess the relationship between PM1, PM2.5 and PM10 concentrations and expression levels of ANRIL. Higher PM10 exposure was related with higher ANRIL expression. In the fully adjusted model higher expression level of ANRIL was related with higher risk of IS (OR = 1.67, 95% CI: 1.22, 2.29, P-value <0.01). Each 1 μg/m3 increase in exposure to PM1, PM2.5 and PM10, the OR of IS increased by 1.04 (95% CI: 1.01, 1.07), 1.03 (95% CI: 1.01, 1.06) and 1.07 (95% CI: 1.03, 1.12), respectively. Our results suggested that PM1, PM2.5 and PM10 could affect IS development by increasing ANRIL expression.